In adult humans, the volume of the hippocampus on each side of the brain is about 3-3.5 cm 3 as compared to 320-420 cm 3 for the volume of the neocortex. Hippocampus is the posterior part of limbic lobe while frontal part is amygdala. It is concerned with hunger, motivation, sex drive, mood, pain, pleasure, appetite, and memory etc. Limbic system is considered to be a “primitive brain,” deep with-in brain. It is the earliest and most severely affected structure in several neuropsychiatric disorders such as Alzheimer's disease (AD), epilepsy etc. This part of brain has been one of the most extensively studied, and atrophy of this region has clinical consequence both potential and real. Note that hippocampus is a C-shaped structure having amygdaloid body at its anterior end, culminating deep into mammillary bodies ( Figure: courtesy AITBS publishers India) Relationship between limbic system and hippocampus.
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